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A cautionary tale: beware the former boyfriend

SF Gate recently ran a frightening cautionary tale that starts with a pretty awful premise - woman dosed on salvia without her knowledge - and ends much worse than you might imagine:

An 18-year-old woman was admitted to a psychiatric hospital, after reportedly smoking marijuana, with schizophrenia-type symptoms. She was agitated, disorganized and hallucinating. Several days later, her former boyfriend revealed that she had unknowingly smoked leaves and leaf extracts of Salvia divinorum added to her marijuana joint. The young woman had a long history of cannabis use with no untoward effects, but had never before used salvia. After increasing self-mutilating behavior in the hospital, she was involuntarily admitted to a closed ward. Despite large doses of intravenously and intramuscularly administered anti-psychotic drugs, she remained highly psychotic, with disordered thinking, delusions, and slow speech. A few nights later, she was transferred to an intensive care unit because of "a marked decrease of alertness." She had developed a toxic psychosis with stupor and catatonic excitement. Because the anti-psychotic medications (Zyprexa and Haldol) were having no useful effect, the young woman was given two series of electroconvulsive treatments, but these were discontinued because she had recurrent episodes in which her heart stopped for periods as long as 5 seconds. Her erratic heartbeat required a temporary external cardiac pacemaker.

In a masterpiece of understatement, the article continues with (italics added by me for emphasis):

Then things started to turn bad .... Her agitation caused her to bite off a 1/2-inch-by- 1/2-inch part of her tongue, which she aspirated, requiring tracheal intubation and ventilation. She developed elevated temperature, a drop in blood pressure and a rigid abdomen. An X-ray showed signs of peritonitis. An exploration of her abdomen disclosed several necrotic (dead, dying) areas of her small intestine and colon, requiring surgical removal of the affected parts.

Erowid contributing editor Lux pointed out, "One thing that is not made particularly clear in this article is that the described necrosis of the small intestine and colon resulted not from the Salvia, but rather from the regimen of antipsychotic meds the poor woman was administered." I suspect the author of the article, Dr. Eugene Schoenfeld, who "practices psychiatry and addiction medicine in Sausalito," overlooked making this point overtly because it seemed obvious to him; I'm giving him credit since his bio indicates, "During the 1960s and 1970s, he provided information about psychoactive drugs through his Dr. Hip Pocrates newspaper columns and radio programs."

The main conclusion to draw, of course, is not that salvia is inherently negative, although it's possible that mainstream media might draw that conclusion. No, the main conclusion is that this woman's former boyfriend, if he indeed turns out to be responsible for dosing her, deserves to be run through a threshing machine.

Fortunately (speaking relatively, of course):

After a long hospitalization, which included decreasing doses of anti-psychotic drugs, her psychotic symptoms resolved and she was discharged in a psychiatrically stable condition.
Posted By Scotto at 2008-11-12 02:11:26 permalink | comments
Tags: salvia
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... : 2008-11-15 14:33:45
I think it's entirely possible that salvia caused this. A similar but not as bad occurrence happened to my girlfriend, she smoked marijuana every day and had a bad trip one evening on a low dose of acid and didn't snap out of it for two weeks. It was the scariest thing i've ever experienced. She was completely delusional but luckily is fine now
Adam L. : 2008-11-15 11:42:29
It sounds like he put PCP in it. Salvia won't metabolize that long no matter what is wrong with you. If anything the experience was exacerbated by the antipsychotics pumped into her body. Salvia is legal, anyone whose attempt to get you on PCP goes so badly would say that. And since that one little failure killed himself anyone would report on this.
josep yao. : 2008-11-12 20:10:00
Everything i have to say has been said in the other comments. I'm proud of you dosenation readers! Especially you edumacated types! :D

seriously though, the guy is a fucking asshole. i feel that it was likely another drug, that they did not think to test for, as the guy withheld that there was "salvia" in the pot. i also feel that unfortunately, if it was a psychedelic crisis, the average medical professional would be woefully unprepared to handle it correctly. (correct me if i am wrong)

i would probably loose it too if i just got shipped off to the hospital, and transfered from ward to ward as i was shocked and medicated against my will! that would be a nightmare.

Silas. : 2008-11-12 16:48:53
As other people have alluded to, the mainstream media is going to turn this into a salvia story, when salvia is a red herring here. My guess would be the boyfriend brought it up because he had to say something, and knew it was legal. Ketamine, PCP, or any number of weird research compounds seems more likely.

Also, INAD, but they medical care they gave this girl seems really sketchy. A well trained med-tox dr would immediately suspect salvia as a real cause, and if she was truly as psychotic and dangerous as the article makes out, and they gave haldol a shot, propofol or barb-induced comas are commonly used for short periods of time.

Anonymous. : 2008-11-12 15:35:57
"It might have depleted some resource or elevated some kind of self-sustaining activity pattern, either of which could have effects long after the drug was itself gone."

An interesting question perhaps, but I don't think that a sensational and misleading article based upon a letter to a peer-reviewed journal (and not the journal itself) helps us to come closer to answering that question!

(And my personal speculation is that the Salvia (if present) had nothing to do with it. I saw some published numbers recently trying to assess how many people had tried or use Salvia, and the estimates are in the millions at this point. This case is such a statistical outlier that some pretty extraordinary evidence would have to be presented to show any causation. But this is just an opinion, of course.)

avicenna : 2008-11-12 14:45:03
It's probably not appearing in PubMed because it is reported in a letter to the editor. I do have access to the journal and just read the letter.

The report does note that the "[somatic several consequences] are likely attributable to the medical treatment of a severe psychotic state rather than the psychosis itself." My guess would be that Dr. Schoenfield did not overtly make this point because in his view because he views the treatment received as medically necessary in light of her condition. I think while it is important to consider that some of the more grisly outcomes she experienced might have been avoided had she been treated less aggressively, it is hard to tell what might have happened. She might have died due to catatonic exhaustion, for example. Also, among the first symptoms she showed was increasingly severe self-mutilation, so not all of her persisting somatic problems can be blamed on her treatment. I think it is understandable to keep the focus on the fact that none of this would have happened if she hadn't been dosed rather than letting it get derailed into questioning the cost/benefit of the standards of care of emergency psychiatry, which can be better addressed outside of isolated case studies.

One other caveat: We don't know whether there were any other adulterants aside from salvia, and in fact don't actually know for sure whether she was exposed to salvia. A hair test did show cannabis consumption, but there is no analagous test for salvia. Salvia was raised as a culprit because the former boyfriend (it is unclear whether he was a then-boyfriend) volunteered that information a few days after her admission to the hospital. The article does not make clear what other potential adulterants were ruled out.

If anyone cares, she has filed legal proceedings against the boyfriend. Bully for her.

To address Jay's comment. The concern here would be that a small portion of the population show an abnormal response to salvia, which throws out the window the pharmacological properties in normals that you note. At a minimum, I don't think anyone is trying to claim that the salvia was still active in her brain days later, rather the concern is that it somehow impaired or altered the functioning of her brain in a way that took a long time to return to normal. It might have depleted some resource or elevated some kind of self-sustaining activity pattern, either of which could have effects long after the drug was itself gone.

duster. : 2008-11-12 14:31:44
the boyfriend could have lied and said salvia when really it was pcp. saliva would be a dirty trick that was over in a few minutes, pcp would be a date-rape move. which do you think?
JRoastD. : 2008-11-12 14:09:12
Jay, thank you for stating what had come to my mind the moment I began reading the article. I do not think a joint containing saliva leaves would be able to cause much damage. I am curious to know what else they found in her system, if they even searched for anything. I am thinking, that the weed could have been dusted by an angle. It is always a possibility.

Brandon. : 2008-11-12 13:53:06
It's there, page 1501 in the 'Leters to the Editor' section.

Also if you read the report itself, the author acknowledges that the somatic symptoms are likely caused by the treatment

Anonymous. : 2008-11-12 12:31:07
You know, maybe I'm stating the obvious, but has anyone tried to do any fact checking? I just spent a little time on-line at Pubmed and the Journal of Clinical Psychiatry's site, and I can find no reference to any article about Salvia in the September 2008 issue, as is claimed by the original article.

My guess is this is a total fabrication. Perhaps someone who has access to the journal can check (I work for a university, but our library doesn't include this journal).

Tedious. : 2008-11-12 08:10:58
I can believe it. She's only 18, smoked pot lots of times, and then one time she smokes a joint and seems to go crazy. If she had any potential mental illness in her, this seems like a perfect chance for it to show up. Once she loses her mental footing, if even for 5 minutes, it could have been very hard to regain her place in reality, particularly in an uncomfortable hospital setting with various hard drugs (I mean prescribed anti-psychotic medications) in her system and eventual electroschock treatments.
Anyway, I'm glad she was eventually back to "normal". Shame on the boyfriend if he really did dose her without her knowledge.
Jay. : 2008-11-12 04:24:10
I call bullshit on her smoking Salvia in the joint. Salvia requires high temperatures and holding it in for a while before you notice the affects. I can't see just putting some salvia into a joint to produce these effects.

The trip itself also only lasts 15 to 30 minutes, not hours/days like described in the article.

Sounds more like LSD or some other longer lasting psychedelic that took a wrong turn on her.

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