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Cannabidiol dilutes THC's effect on memory

More news on the difference between 'skunk' weed and regular marijuana.

Some particular forms of cannabis may contain an ingredient that helps to diminish the drug's negative effects on memory, a new study has suggested.

The new study has revealed that the strain of cannabis makes all the difference, reports Nature.

In a test of short-term memory skills, only users of 'skunk'-type strains exhibited impaired recall when intoxicated, whereas people who smoked hashish or herbal cannabis blends performed equally well whether they were stoned or sober.

The findings suggest that an ingredient more plentiful in some types of marijuana than in others may help to reduce the memory loss that some users suffer.

The key difference between the types of cannabis is the ratio of two chemicals found in all strains. Tetrahydrocannabinol (THC) is the primary active ingredient and the second chemical, cannabidiol.

Valerie Curran of the University College London who led the latest study, said that if habitual users must partake they should be encouraged to use strains with higher levels of cannabidiol, rather than using skunk.

Researchers had been suspecting that any effects of the drug on mental health could be a result of an increased ratio of THC to cannabidiol in cannabis, because levels of cannabidiol have not kept pace with rising THC concentrations.

To test this hypothesis, Curran and her colleagues travelled to the homes of 134 volunteers, where the subjects got high on their own supply before completing a battery of psychological tests designed to measure anxiety, memory recall and other factors such as verbal fluency when both sober and stoned.

The researchers then took a portion of the stash back to their laboratory to test how much THC and cannabidiol it contained.

The subjects were divided into groups of high (samples containing more than 0.75 percent cannabidiol) and low (less than 0.14 percent) cannabidiol exposure, and the data were filtered so that their THC levels were constant.

Analysis showed that participants who had smoked cannabis low in cannabidiol were significantly worse at recalling text than they were when not intoxicated. Those who smoked cannabis high in cannabidiol showed no such impairment.

The results suggested that cannabidiol could mitigate THC's interference with memory formation.

[Thanks Wouldpkr!]

Posted By jamesk at 2010-10-05 12:12:46 permalink | comments
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guest : 2010-10-07 15:25:15
To make it more confusing, in parts of the US at least "skunk" is more associated with indica-dominant hybrid strains than it is with pure sativas. I agree with the other poster - generalizing about "hash" (CBD levels could vary greatly) and "herbal cannabis blends" - the terminology used in this study leaves it completely incoherent.
Spaced out scientists need better theories. : 2010-10-05 21:50:53
There are so many things with this study and article that are not sound.

On one level 'skunk' can mean differnet things.

Around the world it refers to a certain strain of cannabis sativa. In the UK skunk seems to mean potent, fragrant or high grade cannabis to many people.

Then there is this statement:

"only users of 'skunk'-type strains exhibited impaired recall when intoxicated, whereas people who smoked hashish or herbal cannabis blends performed equally well whether they were stoned or sober".

This also confuses things further as some types of hash are made from cannabis sativa and are there fore low in CBD. Not to mention the term 'herbal cannabis blends' - what does that even mean? Cannabis and mint? Isn't all cannabis refered to as 'herbal'? And the term 'blends' tend to mean an admixture of some type.

For the sake of trying to make sense of this bizarre study we will assume the authors mean 'skunk' being cannabis sativa strains versus cannabis indica strains. Since sativa has lower levels of CBD, while cannabis indica can have very high amounts of CBD.

Sativa types of cannabis, while lower in CBD than cannabis indica strains, are also known for being more clear headed, motivated and energetic feeling than indicas.

Pure Indica strains are also known to make people more lazy, tired and even sleepy.

So much so that while some people who may think cannabis causes lethargy or laziness, it may be because they have never had cannabis sativa (indicas are significantly more commonly encountered due to factors such as easier growing techniques).

Any demonstratable memory impairment caused by cannabis consumption in laboratories has also shown to last longer than the day of consumption, though seems to be unnaccountable for after a few weeks without consumption.

This alone shows that on one hand the memory impairing effects of the cannabis being consumed are both not permanent and could also easily last longer than the availability of the variety of the current sample a cannabis user has at home, for cannabis suppliers and users go through different batches regularly.

Further more human memory changes through out the day depending upon sleep and other factors such as diet.

Beyond all of this, being that cannabis indica is much more common than cannabis sativa, it seems highly unlikely that cannabis would be commonly associated with memory impairment since the kind which impairs memory (according to this study) is so much less commonly available.

The comments posted here do not reflect the views of the owners of this site.

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