Antidepressants might not work as well as advertised

Ulp... you mean antidepressants might not be as effective as we thought? Apparently that might be the case:

The makers of antidepressants like Prozac and Paxil never published the results of about a third of the drug trials that they conducted to win government approval, misleading doctors and consumers about the drugs’ true effectiveness, a new analysis has found.

In published trials, about 60 percent of people taking the drugs report significant relief from depression, compared with roughly 40 percent of those on placebo pills. But when the less positive, unpublished trials are included, the advantage shrinks: the drugs outperform placebos, but by a modest margin, concludes the new report, which appears Thursday in The New England Journal of Medicine.

Of course, no one is suggesting that antidepressants aren't a useful tool to have around, but this kind of reporting bias has been around for a while, and yet it's still surprising to see it surfacing over such a significantly prescribed class of substances.