Kids smoking HIV drugs

Kid's have been smoking an HIV drug for centuries, its called marijuana.

So I've been browsing retrovirals. here is a wiki shot of Saquinavir [link]

I am not an organic chemist, but it seems that potentially psychoactive molecules could metabolize from this...

There are no specific drugs mentioned in the article other than anti-retrovirals, which could be a variety of things. However, most ARVs are enzyme-like macromolecules with big chunks of transcriptor RNA hanging off of them. By the time they are burned and smoked and absorbed into the bloodstream they would have broken down into a bunch of different simpler molecules, metabolites, and so on. I could easily imagine the breakdown of large quantities of these types of drugs taken all at once causing some kind of dizziness or disorientation for short periods of time, but it is still messed up. My initial guess is that this is probably a way to get high, but not a good one.

Yeah, it does sound pretty ludicrous, and I immediately thought of the jenkem scare as well, but, you know, it's the BBC, right? In any case, I didn't think HIV drugs were centrally active, although I don't really know anything about their pharmacology. Who knows. It'll be interesting to see what happens with this story, or if it'll dissipate into the ether.

i wanna see the science behind this. Sounds like some jenkem shit to me (no pun intended). i suspect what they are mixing it with is the culprit.

and, normally, i would trust the BBC, but this sounds ludicrous to me.
[link]
the article said that users are exposing themselves to the side effects, and that is quite a list....

Whoa, that's nuts. Why/ how are AIDS/HIV drugs hallucinogenic? That's fucking mindblowing, man. I sorta doubt it, though...